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Enclomiphene citrate is mainly currently being investigated used to treat male topics with chronically very low testosterone levels attributable to secondary hypogonadism. With this problem, small testosterone ranges are due to the dysfunction from the hypothalamic pituitary gonadal (HPG) axis.

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Enclomiphene citrate is the trans isomer of clomiphene citrate and acts as a non-steroidal estrogen receptor antagonist.

The hypothalamus and pituitary glands deliver sexual intercourse hormones during the topics. Any difficulties in these glands may well cause hypogonadism.

Remaining a SERM, Citrate has the potential to bind with estrogen receptors within the study subjects. Following binding, it may quit estrogen manufacturing and signal the Mind to make testosterone. This signaling may well bring on an increase in testosterone amounts within the topics. 

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